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PROTAC® Optimization Kit for BET Bromodomain-Cereblon Binding

●Purchase●DescriptionThePROTAC®OptimizationKitforBETBromodomain-CereblonBindingisdesignedfortestingandprofilingofPROTACs®directedagainstBETBromodomainfamilyandCerebloncomplex

  • 產(chǎn)品型號：79770
  • 廠商性質(zhì)：生產(chǎn)廠家
  • 更新時間：2023-11-11
  • 訪  問  量：259
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Description

The PROTAC® Optimization Kit for BET Bromodomain-Cereblon Binding is designed for testing and profiling of PROTACs® directed against BET Bromodomain family and Cereblon complex. Cereblon (CRBN) is a Substrate recognition component of a DCX (DDB1-CUL44-Rbx1) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

With this kit, only three simple steps on a microtiter plate are required for PROTAC® activity detection. First, a sample containing PROTAC® is incubated with CRBN and BRD3(BD2), one of the BET bromodomains. Next, acceptor beads are added, then donor beads, followed by reading the Alpha-counts.

Assay Principle

This product has been cited 4 times.

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Synonyms
CRBN, Protein X 0001, MRT2A MRT2, Bromodomain containing 3, BRD3, RING3L
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