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●Purchase●DescriptionMS-275,alsoknownasEntinostat,isaninhibitorofhistonedeacetylases(HDACs)andpreferentiallyinhibitsHDAC1overHDAC3
產(chǎn)品型號(hào):27011
廠商性質(zhì):生產(chǎn)廠家
更新時(shí)間:2023-11-11
訪 問(wèn) 量:110
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MS-275, also known as Entinostat, is an inhibitor of histone deacetylases (HDACs) and preferentially inhibits HDAC1 over HDAC3. It does not inhibit HDAC8 (IC50 > 100 µM). It induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo. Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs like adriamycin, inhibitors of PARPs, or inhibitors of Hsp90.
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