This purified rabbit monoclonal antibody recognizes recombinant wildtype SARS-CoV-2 Spike RBD and trimeric spike proteins. Additionally, this antibody cross-reacts with the Delta variant (B.1.617.2) Spike S1 and trimeric proteins and with the Delta Plus variant (B.1.617.2.1) trimer. This antibody also cross reacts with variant Alpha (B.1.1.7; U.K.), Beta (B.1.351; South African), and Gamma (P.1; Brazilian) Spike RBD and trimeric proteins. This neutralizing antibody impedes the interaction between SARS-CoV-2 Spike and human ACE2 receptor. ACE2 receptor is known to mediate infection through direct binding of the SARS-CoV2 Spike protein. This neutralizing antibody has been functionally tested using BPS Bioscience Spike RBD: ACE2 Inhibitor Screening Kits and using Spike pseudotyped lentiviruses in cell-based assays.

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